Research Articles

Diagnostic accuracy of rapid antigen tests in asymptomatic and presymptomatic close contacts of individuals with confirmed SARS-CoV-2 infection: cross sectional study

Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART)

Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study

Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform

Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis

Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence

Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study

Use of cast immobilisation versus removable brace in adults with an ankle fracture: multicentre randomised controlled trial

Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial

Burden, treatment use, and outcome of secondary mitral regurgitation across the spectrum of heart failure: observational cohort study

Effect of the covid-19 pandemic in 2020 on life expectancy across populations in the USA and other high income countries: simulations of provisional mortality data

Mobile health and privacy: cross sectional study

P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial

Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial

Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study

Low and very low carbohydrate diets for diabetes remission

Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries

Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study

Behavioral interventions to improve population health outreach for hepatitis C screening: randomized clinical trial

Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study

Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study

Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)

Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study

Treatment timing and the effects of rhythm control strategy in patients with atrial fibrillation: nationwide cohort study

Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis

Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study

Suicide and self-harm in adult survivors of critical illness: population based cohort study

Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial

Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden

Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study

Delayed antibiotic prescribing for respiratory tract infections: individual patient data meta-analysis

Prophylaxis against covid-19: living systematic review and network meta-analysis

The methodological quality of individual participant data meta-analysis on intervention effects: systematic review

Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies

Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

E-health StandingTall balance exercise for fall prevention in older people: results of a two year randomised controlled trial

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Adherence to the test, trace, and isolate system in the UK: results from 37 nationally representative surveys

Update to living systematic review on drug treatments for covid-19

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis

Age dependent associations of risk factors with heart failure: pooled population based cohort study

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools

Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

Changes in soft drinks purchased by British households associated with the UK soft drinks industry levy: controlled interrupted time series analysis

Update to living systematic review on covid-19 in pregnancy

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Early surgical reconstruction versus rehabilitation with elective delayed reconstruction for patients with anterior cruciate ligament rupture: COMPARE randomised controlled trial

Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study

High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial

SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

Instrumental variable meta-analysis of aggregated randomized drug trial data for evaluating proposed target mechanisms

Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years: prospective, cluster randomised controlled trial in Mumbai

Excess mortality in Wuhan city and other parts of China during the three months of the covid-19 outbreak: findings from nationwide mortality registries

Covid-19 deaths in Africa: prospective systematic postmortem surveillance study

Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018

Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study

Association between antihypertensive treatment and adverse events: systematic review and meta-analysis

Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study

Update to living systematic review on prediction models for diagnosis and prognosis of covid-19

Effect of redundant clinical trials from mainland China evaluating statins in patients with coronary artery disease: cross sectional study

Association between human papillomavirus vaccination and serious adverse events in South Korean adolescent girls: nationwide cohort study

Association between county level cannabis dispensary counts and opioid related mortality rates in the United States: panel data study

Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial

Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial

Association between home insulation and hospital admission rates: retrospective cohort study using linked data from a national intervention programme

Update to living systematic review on drug treatments for covid-19

Does medicine run in the family—evidence from three generations of physicians in Sweden: retrospective observational study

Association of high profile football matches in Europe with traffic accidents in Asia: archival study