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Research methods & reporting

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Extension of the PRISMA 2020 statement for living systematic reviews (PRISMA-LSR): checklist and explanation

November 19, 2024

Reading and conducting instrumental variable studies

October 14, 2024

Recommendations on recording harms in randomised controlled trials of behaviour change interventions

October 2, 2024

Developing clinical prediction models: a step-by-step guide

September 3, 2024

Reporting on data sharing: executive position of the EQUATOR Network

August 13, 2024

Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration

July 9, 2024

Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration

July 9, 2024

Exploring different objectives in non-inferiority trials

June 17, 2024

ROBVALU: a tool for assessing risk of bias in studies about people’s values, utilities, or importance of health outcomes

June 12, 2024

Guidance on terminology, application, and reporting of citation searching: the TARCiS statement

May 9, 2024

TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods

April 16, 2024

Quantifying possible bias in clinical and epidemiological studies with quantitative bias analysis: common approaches and limitations

April 2, 2024

Assessing robustness to worst case publication bias using a simple subset meta-analysis

March 15, 2024

Regression discontinuity design studies: a guide for health researchers

February 27, 2024

Process guide for inferential studies using healthcare data from routine clinical practice to evaluate causal effects of drugs

February 12, 2024

Updated recommendations for the Cochrane rapid review methods guidance for rapid reviews of effectiveness

February 6, 2024

Avoiding conflicts of interest and reputational risks associated with population research on food and nutrition

January 29, 2024

The estimands framework: a primer on the ICH E9(R1) addendum

January 23, 2024

Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study

January 22, 2024

Evaluation of clinical prediction models (part 2): how to undertake an external validation study

January 15, 2024

Evaluation of clinical prediction models (part 1): from development to external validation

January 8, 2024

Emulation of a target trial using electronic health records and a nested case-control design

December 28, 2023

ROB-ME: a tool for assessing risk of bias due to missing evidence in systematic reviews with meta-analysis

November 20, 2023

Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance

October 20, 2023

Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance

October 20, 2023

Understanding how health interventions or exposures produce their effects using mediation analysis

July 19, 2023

A guide and pragmatic considerations for applying GRADE to network meta-analysis

June 27, 2023

A framework for assessing selection and misclassification bias in mendelian randomisation studies: an illustrative example between BMI and covid-19

June 19, 2023

Practical thematic analysis: a guide for multidisciplinary health services research teams engaging in qualitative analysis

June 8, 2023

Selection bias due to conditioning on a collider

June 7, 2023

The imprinting effect of covid-19 vaccines: an expected selection bias in observational studies

June 7, 2023

A step-by-step approach for selecting an optimal minimal important difference

May 26, 2023

Recommendations for the development, implementation, and reporting of control interventions in trials of self-management therapies

May 25, 2023

Methods for deriving risk difference (absolute risk reduction) from a meta-analysis

May 5, 2023

Transparent reporting of multivariable prediction models for individual prognosis or diagnosis: checklist for systematic reviews and meta-analyses

May 3, 2023

CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomised trials

April 24, 2023

Transparent reporting of multivariable prediction models: : explanation and elaboration

February 7, 2023

Transparent reporting of multivariable prediction models: TRIPOD-Cluster checklist

February 7, 2023

Bias by censoring for competing events in survival analysis

September 13, 2022

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

August 29, 2022

Validation of prediction models in the presence of competing risks

May 24, 2022

Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence

May 18, 2022

Searching clinical trials registers: guide for systematic reviewers

April 26, 2022

How to design high quality acupuncture trials—a consensus informed by evidence

March 30, 2022

Early phase clinical trials extension to guidelines for the content of statistical analysis plans

February 7, 2022

Incorporating dose effects in network meta-analysis

January 18, 2022

Consolidated Health Economic Evaluation Reporting Standards 2022 statement

January 11, 2022

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

October 26, 2021

A new framework for developing and evaluating complex interventions

September 30, 2021

Adapting interventions to new contexts—the ADAPT guidance

August 3, 2021

Recommendations for including or reviewing patient reported outcome endpoints in grant applications

June 30, 2021

CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

April 30, 2021

CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

April 30, 2021

CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data

April 30, 2021

Guidance for the design and reporting of studies evaluating the clinical performance of tests for present or past SARS-CoV-2 infection

March 29, 2021

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

March 29, 2021

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

March 29, 2021

Preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts): checklist, explanation, and elaboration

March 15, 2021

Designing and undertaking randomised implementation trials: guide for researchers

January 18, 2021

STaRT-RWE: structured template for planning and reporting on the implementation of real world evidence studies

January 12, 2021

Methodological standards for qualitative and mixed methods patient centered outcomes research

December 23, 2020

GRADE approach to drawing conclusions from a network meta-analysis using a minimally contextualised framework

November 11, 2020

GRADE approach to drawing conclusions from a network meta-analysis using a partially contextualised framework

November 10, 2020

Use of multiple period, cluster randomised, crossover trial designs for comparative effectiveness research

November 4, 2020

When to replicate systematic reviews of interventions: consensus checklist

September 15, 2020

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension

September 9, 2020

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension

September 9, 2020

Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): explanation, elaboration, and checklist

August 14, 2020

Non-adherence in non-inferiority trials: pitfalls and recommendations

July 1, 2020

The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

June 17, 2020

Machine learning and artificial intelligence research for patient benefit: 20 critical questions on transparency, replicability, ethics, and effectiveness

March 20, 2020

Calculating the sample size required for developing a clinical prediction model

March 18, 2020

SPIRIT extension and elaboration for n-of-1 trials: SPENT 2019 checklist

February 27, 2020

Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline

January 16, 2020

Alternative approaches for confounding adjustment in observational studies using weighting based on the propensity score: a primer for practitioners

October 23, 2019

A guide to prospective meta-analysis

October 9, 2019

RoB 2: a revised tool for assessing risk of bias in randomised trials

August 28, 2019

CONSORT 2010 statement: extension to randomised crossover trials

July 31, 2019

When and how to use data from randomised trials to develop or validate prognostic models

May 29, 2019

Guide to presenting clinical prediction models for use in clinical settings

April 17, 2019

A guide to systematic review and meta-analysis of prognostic factor studies

January 30, 2019

When continuous outcomes are measured using different scales: guide for meta-analysis and interpretation

January 22, 2019

The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE)

November 14, 2018

Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration

November 9, 2018

DELTA,2, guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

November 5, 2018

Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews

September 28, 2018

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

July 12, 2018

How to use FDA drug approval documents for evidence syntheses

July 10, 2018

How to avoid common problems when using ClinicalTrials.gov in research: 10 issues to consider

May 25, 2018

TIDieR-PHP: a reporting guideline for population health and policy interventions

May 16, 2018

Analysis of cluster randomised trials with an assessment of outcome at baseline

March 20, 2018

Key design considerations for adaptive clinical trials: a primer for clinicians

March 8, 2018

Population attributable fraction

February 22, 2018

How to estimate the effect of treatment duration on survival outcomes using observational data

February 1, 2018

Concerns about composite reference standards in diagnostic research

January 18, 2018

Statistical methods to compare functional outcomes in randomized controlled trials with high mortality

January 3, 2018

CONSORT-Equity 2017 extension and elaboration for better reporting of health equity in randomised trials

November 23, 2017

Handling time varying confounding in observational research

October 16, 2017

Four study design principles for genetic investigations using next generation sequencing

October 12, 2017

AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both

September 21, 2017
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